© 2019 by Ellen J. Hoffman

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Lab Members

Ellen J. Hoffman, MD, PhD

Principal Investigator

Email: ellen.hoffman@yale.edu

Ellen studied Biochemistry at SUNY Stony Brook and received her MD from SUNY Stony Brook School of Medicine. As a medical student, she worked in the laboratory of Gail Mandel of the Howard Hughes Medical Institute. Ellen did her residency in Psychiatry and fellowship in Child and Adolescent Psychiatry at Mount Sinai School of Medicine, where she worked in the laboratories of Deanna Benson and Joseph Buxbaum. She then completed a research fellowship in Childhood-Onset Neuropsychiatric Disorders at the Yale Child Study Center and received her PhD in Investigative Medicine from Yale University in the laboratories of Matthew State and Antonio Giraldez. She is currently an Assistant Professor in the Yale Child Study Center and the Yale Neurogenetics Program.

Christina Szi

Post-Graduate Associate

Email: christina.szi@yale.edu

Christina graduated from Haverford College with a B.S. in Biology and a minor in Neuroscience. At Haverford she worked in the Jain lab, where she investigated where the ap2s1 gene acts during short term learning in larval zebrafish. Christina joined the Hoffman lab in June 2018, where her project focuses on characterizing behavioral differences, high throughput imaging and screening of pharmacological compounds in zebrafish carrying mutations in genes strongly associated with autism spectrum disorders in humans. 

Tianying Chen

Post-Graduate Associate

Email: tianying.chen@yale.edu

Tianying received her B.S. in Biology from Beijing Normal University and her Master's Degree in Biochemistry and Cell Biology at SUNY Stony Brook. She worked in Benjamin Martin's lab at Stony Brook, where she investigated the effect of retinol acid on angioblast migration during early zebrafish development and the role of tcf15 in mesodermal patterning. Tianying joined the Hoffman lab in February 2019. Her work focuses on investigating changes in brain structure in zebrafish mutants of ASD risk genes.

Brendan Rooney

Undergraduate Student 

Email: brendan.rooney@yale.edu

Brendan is currently a senior in Yale College majoring in Molecular, Cellular, and Developmental Biology (MCDB). Since joining the lab in June 2017, Brendan has helped the lab investigate the role of ASD-risk genes in neurodevelopment. Brendan has been especially involved in identifying pharmacological treatments that may help elucidate the underlying dysregulated neural circuitry of ASD-risk gene mutants.

Kristen Enriquez

Undergraduate Student 

Email: kristen.enriquez@yale.edu

Kristen is a junior in Yale College majoring in Molecular, Cellular, and Developmental Biology (MCDB). She joined the Hoffman lab in June 2018, where her project focuses on defining behavioral phenotypes of zebrafish mutants of ASD risk genes. Kristen is involved in identifying differences in brain structure and activity in ASD-risk gene mutants, and how these differences predispose to behavioral dysfunction.